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APOE Genetics - What Do These Lab Tests Mean?

Updated: Aug 28, 2023


Happy functional medicine Friday, Dr. Julie McLaughlin here with McLaughlin care. So today we're gonna talk about another lab test panel, and this one is on genetics and is on one test called APOE. So, what does that mean? Right. Did you ever wonder, why do some diets work for some people and not for others?

Like some people they'll do keto and they do great. And other people they're like, oh, I did terrible. Some people do vegetarian and they're doing great. And some people don't. But why? And so you always hear, 'em like, well, you didn't do it right. Well, you didn't eat the right thing. Well, you ate this or, you know. There's another answer. It's in our jeans.

When we're born, we get certain cards, right. We get certain jeans and those cards are what you get. You have 'em for your whole life. And it's whether or not they express themselves or how they express themselves. And we can change that with our food, our nutrients that we take, and our lifestyle, because you don't wanna just let it go and throw everything up in the air and say, well, it's all my Gene's fault. No, you can absolutely control what's going on with those genes. And that process is called nutrigenomics, and this is how our genes interact with food.

When we look at the APOE, this is really what makes us unique. We get one from our mom and one from our dad, and this is a great gene to help us know how we're going to interact with certain nutrients and with the food we consume. APOE is really a critical protein in our cholesterol, and it it's important for cholesterol absorption from the intestines. So you can imagine if you absorb too much, you're gonna have high cholesterol. And if you don't absorb enough, you're gonna have low cholesterols. Do you see how that can affect.

So when we talk about this, sometimes the genetics can get a little tricky. I'm gonna give you a little refresher course. And the easiest thing is the male female, right. Female is X, X, and male is X. Y we get one allele from each parent. The Y determines the differentiation in the sex. So if you have a Y you're a male, and if you have two Xes, you're female, but in the male, they still have the X, but the Y makes the difference. So in the APOE it's really similar.

There's a three, three, right? The three is the thing that's pretty much common. And the three most common genotypes in this APOE are a three, a two, and a four. So there's some others that are pretty rare, but I'll tell you about those two in a second. So the three, three, you have a three from your mom, a three from your dad, right? Or a two, three. So if you get one from your mom, one from your dad, it makes you a two, right? So just like that y in the male thing that you're a two. If you have a three, four, then you're a four. Now the very rare ones, like less than 1% of a percentage, right? You could have a two, two, a four, four. Or a two, four.

So the two, four is very tricky. And we'll talk about that in a second. When we look at these, we wanna know what do tigers eat, right? Tigers, eat meat, their carnivores, but what about bears their omnivore. So they eat a little bit of plants. They eat a little bit of berries. They eat some fish. There might eat some animals. So they're omnivores. What about deer? They're pretty much veggie eaters. They're vegetarians. So guess what? We're the same way, but we can go to the grocery store and buy and eat whatever we want, but some of our genes are gonna be targeted to help us control those genes with our food.

So when we look at the APOE. Remember, there's gonna be the three main genotypes we're gonna talk about. So the 3 they're bears, they're like a omnivore they're middle of the road, and that's where we wanna be. 50% of your plate should be complex carbohydrates and 50% should be protein and fat. The deer. They're gonna be more veggie eaters.

Those are the people with the APOE 4, and they're gonna be more susceptible to heart disease and Alzheimer's, and you're like, what heck I don't, I don't want that. So if you have that vegetarian, you know, leaner, protein, chicken, and fish lifestyle, you're going to do much better. With that type of genotype. Now the tigers they are the opposite, they're more susceptible to diabetes and they're gonna be better eating like a carnivore, like a tiger.

So I'm giving you a brief overview, but I'm gonna give you a chance here at the end of the video to have a little bit deeper dive. So on the three. We look at what is the risk? 65% of the population has this genotype. It's the most common one. It means you're middle of the road. You don't have higher risk from this one gene, you might have other genes, but from this one you don't. Remember, 50% of your plate should be complex carbohydrates and 50% should be protein and fat.

If you're a two, a tiger. That's what I am. Diabetes runs in my family. Sometimes you can kind of guess what you might be by looking at your family history, who has heart disease, diabetes, things like that. So only 10% of people in the world are tigers or twos, right? And they're more susceptible to diabetes, but it's very heart and brain protective. So the risk of Alzheimer's is very, very diminished and the risk of high cholesterol and heart disease is very, very diminished. Except if you turn on the diabetic gene, All bets are off. Everything goes crazy. So these people should eat more ketos, like 70% other plates should be protein in fat and 30% should be complex carbohydrates.

In the last one they're gonna be deer. So 25% of the population are gonna be deer, more susceptible to heart disease and Alzheimer. These people wanna have 60% of their plate complex carbohydrates and only 40% protein and fat. We have to have that balance because we don't wanna turn on any of those negative side effects.

There's a lot more information that I have on each one of those genotypes that I go through. And if you wanna learn more, I'm gonna give you an opportunity. We have online courses that we have taught, and they're recorded and they have downloads and handouts and pictures and all kinds of things for you.

And it's on and the course is called eating for your genes. And if you go on there now and type in the promo code summer 22, you will get that course for FREE, and then you can learn some more. So if you have any questions, let me know.


I hope you have a great day. See you next time.

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